Category Archives: Science and Technology

Genre Blender

 

Genres are cool and useful guides to what a story is about. If I tell you a story is a horror you know that you should feel tense and unsettled as it unfolds and perhaps even after it is over. If it is a romance, you will hopefully feel joy and fulfillment by the end. When two genres are combined then something truly wonderful and magical is possible. Alien the movie that launched countless imitations artfully blended science-fiction with horror, it was by far not the first to do so but its unparalleled quality elevated it above the material that had come before. My own novel Vulcan’s Forge is a combination of colonial science-fiction and 40s styled film noir.

I have started in on a short story blending two genres that are wildly different and I hope I have the skill to pull it off even halfway decently, forward-looking science-fiction and tradition oriented folk horror.

Folk horror is a sub-genre of horror fiction that fixates on isolated usually rural setting and communities where the old ways are not only now forgotten but are usually embraced and practiced with zealotry. Where strangers confronted with unknown customs and filled with derision for these communities often meet untimely fates. A perfect example of this style of horror and one of my favorite films is 1973’s The Wicker Man.

I think science-fiction, with its emphasis on the new, the novel, and the future makes for an excellent contrast with folk horror with its dedication to tradition, custom, and the wisdom of the past. I hope I can do justice to moth forms.

 

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Potentially Amazing Good News

 

Running a little late this morning but I do have some public health news to share that is potentially amazing.

The fight against the global pandemic of COVID-19 sped the development, testing, and eventual approval of a new approach to vaccines, using messenger RNA to have the body produces elements of the target virus to train the immune system for when an actual infection arrives. This is the basis for the Pfizer and Moderna vaccines which are proving to be so gloriously effective. The basic science and technique of using mRNA for a vaccine approach has been in

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the works for many years, basic science funded by government grants with an eye to many deadly viruses that we haven’t yet produced a vaccine for.

In a press release yesterday Moderna announced that it has two mRNA candidates, mRNA-1644 and mRNA-1574 that is plans to advance for phase 1 trails this year as potential vaccines for HIV.

Now there is a lot that can go wrong between here and approval and even if it doesn’t this will be a long road if for no other reason that large scale efficacy on a disease that progresses so slowly will take lots of time but this is a glimmer of the dawn of a new day, not just against HIV/AIDS, which still kills far too many people around the globe, but also for the fight against so many other tricky, nasty, viruses out there still out to get us.

 

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